Health news

Last update (UTC): 06:46 - 18/02/2026

The Lancet

[Editorial] Statin safety: when warnings outlive the evidence

00:00 - 14/02/2026
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More than 30 years after the Scandinavian Simvastatin Survival Study showed that statins save lives, their full public health potential remains unrealised. Statins are underused worldwide, and as a result, millions of people remain at risk of cardiovascular events that statins could help prevent. The reasons for this implementation gap are complex, but persistent concerns about safety continue to affect both prescribing practices and adherence. Fear of side-effects—such as muscle pain, fatigue, sleep disturbances, and perceived cognitive effects—is a major driver of statin therapy discontinuation, even though randomised nocebo trials have shown that most reported symptoms are attributable to expectation rather than to the drug itself.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00303-X/fullt


[Comment] Continued hope for late neuroprotection with minocycline

00:00 - 30/01/2026
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Neuroprotection in ischaemic stroke commonly means a treatment that results in the preservation of brain tissue in the setting of either focal or global ischaemia. The nominal focus on neuronal tissue—the neuro in neuroprotection—might be misplaced, as the ultimate goal is preservation of the entirety of the relevant tissue, including neurons, glia, vascular elements, and structural tissue. Cytoprotection of the neurovascular unit1 could be a better term.2 Neuronal intolerance to ischaemia is highly time dependent, and mechanisms to protect neurons could also protect and salvage other cellular elements that remain viable after longer durations of ischaemia.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00047-4/fullt


[Comment] Product labels downplay the safety of statin therapy: evidence from randomised controlled trials

00:00 - 05/02/2026
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Following the frequent suspicions regarding the safety of cholesterol-lowering drugs in the pre-statin era,1 statins have been a recurrent object of various concerns and alarming news. For example, during the 1990s, statins were even suspected to promote serious non-vascular outcomes, such as cancer.2 But after the clear-cut results of the Scandinavian Simvastatin Survival Study (4S), which showed the reduction of all-cause mortality in patients with coronary disease,3 and several large-scale clinical trials with corroborating evidence,4 concerns would have been expected to be silenced, but these concerns have persisted in cholesterol sceptics.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02013-6/fullt


[Comment] Implementation first: lessons from the TRICORDER trial in UK primary care

00:00 - 28/01/2026
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Primary care faces a growing workload and limited resources, making it the ideal recipient of the efficiencies promised by artificial intelligence (AI). The potential of AI to improve diagnostic accuracy through decision support systems or image analysis is clear.1–3 However, implementing these tools into primary care workflows remains challenging. Integration into the electronic health record (EHR), management of automation bias, and disruption of the physician–patient relationship are persistent challenges that must be incorporated into the study design itself using pragmatic trials.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02584-X/fullt


[Comment] Four paradigm shifts to shape an agenda for global health reforms

00:00 - 16/01/2026
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Struck by substantial funding cuts throughout 2025, the global health community stands at a crossroads.1 Notwithstanding the grave consequences of decreased international financing, this crisis offers an unprecedented chance to address the well known flaws in the current system. Although the notion that we should first stabilise and later transform the global health landscape has gained traction, it fails to recognise that the present sense of urgency is precisely what makes systemic change possible, and that those two processes should therefore happen in tandem.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02634-0/fullt


[Comment] Hospitals as tenants: the rise of real estate investment trusts in health-care delivery

00:00 - 31/03/2025
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As financial actors including private equity funds increasingly buy and sell hospitals, nursing homes, and physician practices, real estate investment trusts (REITs) have emerged as a form of financial ownership in which the REIT owns the real estate properies of health-care facilities and health-care providers pay rent to the REIT.1 Given the rise of REITs in health care and their expanding global influence, policy makers should take a proactive stance towards regulating health-care REITs to disincentivise short-term profiteering and encourage long-term health-care investments that promote patient access and health-care quality.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00498-2/fullt


[Comment] Expression of Concern: Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

00:00 - 03/02/2026
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Following the publication of this Case Report by Gideon Koren and colleagues1 in 2006, concerns were raised about its interpretation by D Nicholas Bateman and colleagues and we published a Correspondence exchange and an accompanying Comment in 2008.2–4 In 2020, further doubts about the plausibility were raised by David N Juurlink, who asked us to retract the paper and subsequently outlined in a Mini-Review5 together with his colleague Jonathan Zipursky his reasoning for the implausibility of this infant's death being caused through codeine in breastmilk.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00245-X/fullt


[Comment] Offline: Meditations of melancholy

00:00 - 14/02/2026
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So here we are. An email last week: “tensions are very high...one has little control over the chaos of the moment. I'm so angry, and so sad. It's exhausting”. These feelings, I suspect, are pervasive. A fractured world order, with the dismantling of systems that have shaped and stabilised societies, has provoked a surge of uncertainty. People are apprehensive, uneasy, fearful, troubled, disturbed, tense, even distraught. One can understand why. A cruel war of attrition in Ukraine. A terrifying humanitarian catastrophe in Sudan.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00296-5/fullt


[World Report] The end of animal testing?

00:00 - 14/02/2026
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Both the UK and US Governments have pledged to end research using animals, but is such a goal realistic? And how might it change medical research? Talha Burki reports.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00298-9/fullt


[World Report] Critical shortage of blood products in Afghanistan

00:00 - 14/02/2026
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A lack of factor IX and factor VIII has left patients facing disability or death. Samaan Lateef reports.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00299-0/fullt


The Lancet Online

[Comment] New dietary guidelines for Americans: a recipe for poorer health

00:00 - 16/02/2026
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On Jan 7, 2026, the US Departments of Health and Human Services (HHS) and Agriculture (USDA) published the 10th edition of the Dietary Guidelines for Americans (DGA).1 The new DGA are consequential, shaping personal nutritional advice and federal programmes until 2030. Yet the new DGA upended a rigorous, transparent process developed over decades and substituted a conflicted and compromised process that produced contradictory and often unscientific guidelines.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00300-4/fullt


[Correspondence] Dietary evidence and the 2025–2030 US guidelines

00:00 - 16/02/2026
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The 2025–2030 Dietary Guidelines for Americans, jointly issued by the US Departments of Health and Human Services and Agriculture, introduce a revised dietary pyramid that prioritises animal-based protein sources, full-fat dairy products, and saturated fats.1 We wish to comment on the extent to which this framework is supported by, and coherent with, the current body of global nutritional evidence.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00104-2/fullt


[Correspondence] Rethinking current famine classification: insights from history

00:00 - 13/02/2026
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The mass starvation in Gaza has called into question how famine is defined and measured. On Aug 22, 2025, the Famine Review Committee of the Integrated Food Security Phase Classification (IPC) determined that the food situation in Gaza Governorate had reached phase 5: famine.1 This famine status followed repeated warnings from humanitarian organisations and medical professionals that starvation deaths and acute malnutrition among children were rising sharply due to Israeli Government policies and Israel Defense Forces' actions in the Gaza Strip, including denying humanitarian aid.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00214-X/fullt


[Articles] Lisocabtagene maraleucel in patients with relapsed or refractory marginal zone lymphoma (TRANSCEND FL): primary analysis results from the global, multicohort, single-arm, phase 2 study

00:00 - 12/02/2026
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In patients with relapsed or refractory MZL, lisocabtagene maraleucel showed high rates of durable responses. The safety profile was manageable, with no new safety signals. These results support lisocabtagene maraleucel as a new treatment option for patients with relapsed or refractory MZL.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02435-3/fullt


[Therapeutics] New drug therapies for hypertension

00:00 - 10/02/2026
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Despite the availability of effective antihypertensive therapies, global blood pressure control rates remain unacceptably low. Contributing factors, such as low treatment adherence, therapeutic inertia, and rising multimorbidity, underscore the need for innovative approaches to improve hypertension care. New antihypertensive drug therapies that act on physiological pathways beyond those targeted by conventional drug classes are emerging. These therapies include small interfering RNA agents that inhibit angiotensinogen synthesis as a novel approach to inhibit the renin–angiotensin system, and new strategies to more selectively modulate aldosterone, such as aldosterone synthase inhibitors and non-steroidal mineralocorticoid receptor antagonists.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02064-1/fullt


[Comment] Mutually reinforced burdens of obesity and infections

00:00 - 09/02/2026
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Obesity is associated with multiple non-communicable diseases (such as type 2 diabetes, various cardiovascular and musculoskeletal diseases, and some cancers) and detrimental psychosocial consequences originating in the societal attitudes to obesity, leading to stigmatisation and discrimination.1 The contribution of obesity to communicable diseases has been recognised in the past but thought to play a minor role.2,3 However, during the recent COVID-19 pandemic, presence of obesity and its comorbidities appeared to be an important risk factor for a severe course of the infection.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02605-4/fullt


[Articles] Adult obesity and risk of severe infections: a multicohort study with global burden estimates

00:00 - 09/02/2026
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Adult obesity is a risk factor for infection-related hospitalisations and mortality across diverse pathogen types, populations, and baseline clinical profiles, with evidence suggesting that approximately one in ten infection-related deaths worldwide might be attributable to obesity.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02474-2/fullt


[Correspondence] New approaches for UK–China global health cooperation

00:00 - 06/02/2026
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Global health faces unprecedented strain and challenges to its legitimacy. The health-related Sustainable Development Goals and progress towards universal health coverage are off track, and multilateral cooperation is suffering due to geopolitical tensions. The future of global health is likely to be less aid-based and more reliant on domestic financing in low-income and middle-income countries (LMICs), more equitable markets for access to health technologies and digitally mediated treatment guidelines, and strengthened country capabilities.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00219-9/fullt


[Comment] Venezuela's health system: when force meets fragility

00:00 - 05/02/2026
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The US military strikes on Venezuela on Jan 3, 2026 and seizure of the country's President Nicolás Maduro represent a profound shock to a health system already in collapse. With US President Donald Trump asserting that the US Government will run Venezuela for an unspecified period,1 the question is stark: will this claimed stabilisation help restore essential health services or will it deepen disruption and affect the most vulnerable populations?

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00203-5/fullt


[Comment] Intravenous tenecteplase for acute ischaemic stroke within 24 h due to basilar artery occlusion

00:00 - 05/02/2026
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Basilar artery occlusion is a devastating condition with dismal prognosis and constitutes the most severe presentation of acute ischaemic stroke due to large-vessel occlusion.1 Randomised evidence on the safety and efficacy of intravenous thrombolysis in this stroke subtype is scarce, especially outside the conventional 0–4·5 h window.1,2 Tenecteplase is a third-generation tissue plasminogen activator with higher fibrin specificity and longer half-life than alteplase.3 Accruing randomised and observational evidence supports the superiority of tenecteplase over alteplase in patients who have had an acute ischaemic stroke, particularly those with large-vessel occlusion, in improving 3-month functional outcome assessed by the modified Rankin scale (mRS) score.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00139-X/fullt


healthtechmagazine.net

How Smart Hospitals Push Forward From Pilot to Practice

17:26 - 16/02/2026
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An Apple iPad device stationed outside of a hospital room glows yellow, indicating that the patient inside is a fall risk. Before the clinician enters, she touches the screen to view other updates and confirm that she doesn’t need to first check in at the nurse’s station. Inside, a digital whiteboard displays information typically handwritten on a hospital room dry-erase board, such as dietary restrictions and the names of the current care staff. Because the interactive screen is connected to the electronic health record system, the data is updated in real time and can include physical...

https://healthtechmagazine.net/article/2026/02/how-smart-hospitals-push-forward-


Partnerships Push Innovation in the Aging Tech Space

13:21 - 12/02/2026
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A connecting theme during the 2025 LeadingAge Annual Meeting last fall was the importance of involving older adults in the adoption of new technologies that are meant to help with their care. They’re a large, growing market, yet their needs may not be met with newer designs. “The assumption is that older adults don’t like technology, or that they don’t use it, or that they’re afraid of it, or that they don’t understand it. What we’ve really found is that that’s not the case,” Michelle Curnow, senior vice president of sales and brand at Asbury Communities, said during a conference...

https://healthtechmagazine.net/article/2026/02/partnerships-push-innovation-agin


Review: Box Facilitates Secure Collaboration for Healthcare Workers

14:06 - 11/02/2026
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A content management program in healthcare needs to be fully secure, protecting data at rest and in transit, with varying security levels for content being held and managed by the platform. Ideally, data should be standardized so that multiple platforms are not required, and users should be trained on a single content management platform, regardless of which department they work in. The cloud-based Box Intelligent Content Management platform was created to meet the needs of even the most rigorously regulated and protected environments. I recently tested Box in a lab environment, and...

https://healthtechmagazine.net/article/2026/02/review-box-facilitates-secure-col


Getting Smart With Virtual Assistants in Healthcare

13:35 - 10/02/2026
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Last year, Mayo Clinic launched Nurse Virtual Assistant, a generative artificial intelligence tool designed by and for nurses to ease access to patient care, institutional and industry information. Instead of spending hours sifting through the electronic health record system or a clinical policy library, Nurse Virtual Assistant curates a summary in one place. As a large healthcare organization, Mayo Clinic built its solution in-house and will continue to refine it with direct feedback from nurses. Such a tool may feel out of reach for many healthcare providers, but the lesson here is that...

https://healthtechmagazine.net/article/2026/02/getting-smart-virtual-assistants-


A Guide to Cloud Cost Optimization in Healthcare

16:13 - 09/02/2026
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As hospitals and health systems layer artificial intelligence–driven analytics, clinical decision support and automation onto already complex IT environments, cloud costs are becoming harder to predict — and even harder to control. The challenge is no longer simply choosing between on-premises and public cloud but learning how to operate both intelligently at the same time. To keep costs under control, organizations must combine robust FinOps practices with a clear approach to cloud cost governance that aligns technology decisions with clinical, operational and financial priorities. DISCOVER...

https://healthtechmagazine.net/article/2026/02/guide-cloud-cost-optimization-hea


4 Health Tech Trends To Watch in 2026

13:29 - 05/02/2026
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In the wake of a new wave of artificial intelligence tools, healthcare organizations are embracing innovation on a larger scale. The promise of increased efficiency is attractive as the industry faces rising costs of care, demand for seamless patient experiences and growing cybersecurity complexity. While health systems are adopting AI tools on a larger scale, the speed of innovation has forced many to re-evaluate their technology foundations — infrastructure, data governance, cybersecurity — to ensure they can take advantage of AI to the fullest. This year, HealthTech expects healthcare...

https://healthtechmagazine.net/article/2026/02/4-health-tech-trends-watch-2026


Here’s How Healthcare Organizations Can Prepare for Quantum Risk

13:21 - 04/02/2026
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It could take a supercomputer 149 million years to decrypt data that has been encrypted with the RSA-2048 public-key encryption system. A quantum computer might be able to crack that data in eight hours. While quantum computers with this capability don’t yet exist, experts predict they may become available roughly over the next decade. But the power of quantum computing represents an issue that healthcare organizations should start addressing now. “Cryptographers have known for a few decades that if we are able to build a big enough quantum computer, it will threaten all of the public-key...

https://healthtechmagazine.net/article/2026/02/heres-how-healthcare-organization


Review: Delivering Printed Receipts in the Digital Age

15:51 - 03/02/2026
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Despite healthcare’s increasingly digitized workflows, paper will find its way in, especially when there are still patients who prefer having hard copies in hand. For those cases, and for caregivers on the go, the Brother PocketJet 823 mobile printer is a fitting solution. Paramedics and mobile health clinics especially will find uses for this handy portable printer. Providers who need to print receipts, test results or other important documents can rely on this portable thermal printer when paper workflows are needed in a mobile setting, whether working as a visiting nurse or specialist...

https://healthtechmagazine.net/article/2026/02/review-delivering-printed-receipt


Preparing an AI-Ready Nursing Workforce: How Informatics Bridges Technology and Patient Care

12:09 - 02/02/2026
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Artificial intelligence is transforming healthcare at a pace few could have imagined even six years ago. But nursing informatics professionals who understand patient care and data science are central to preparing an AI-ready clinical workforce. In my experience across hospitals, academia and consulting, I’ve learned that technology alone does not improve patient care — people do. As digital transformation accelerates, nurses remain essential to ensuring that AI increases patient safety rather than introducing new risks. Nursing informatics provides the bridge between innovation and practice,...

https://healthtechmagazine.net/article/2026/02/preparing-ai-ready-nursing-workfo


How Health Systems Can Optimize Their Virtualization Strategy

13:22 - 30/01/2026
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Virtualization allows institutions such as health systems to access applications virtually from a single machine and distribute them to other computing environments throughout the organization. In fact, virtualization is the technology that enables cloud computing environments. In 2023, Broadcom acquired VMware, and health systems have been evaluating what that means for their virtualization strategy. However, Broadcom is still offering VMware software, such as VMware Cloud Foundation (VCF), which delivers both the scale of public cloud and the security of private cloud. Broadcom now offers a...

https://healthtechmagazine.net/article/2026/01/how-health-systems-can-optimize-t


GP Online

NICE backs landmark diabetes shift to save 17,000 lives in three years

00:01 - 18/02/2026
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New guidance hailed by NICE as the biggest shakeup of diabetes care in a decade could prevent around 17,000 deaths over three years and save the NHS hundreds of millions of pounds.

https://www.gponline.com/nice-backs-landmark-diabetes-shift-save-17000-lives-thr


NHS to ramp up GP contract focus on diabetes and child vaccination

10:30 - 17/02/2026
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Next year's GP contract - expected imminently - will see a stronger focus on diabetes and child vaccination, NHS officials have said.

https://www.gponline.com/nhs-ramp-gp-contract-focus-diabetes-child-vaccination/a


DAUK urges rethink on GMC fees for doctors taking parental leave

13:24 - 13/02/2026
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The Doctors’ Association UK (DAUK) wants the GMC to introduce a specific fee reduction for doctors, including GPs, who take parental leave.

https://www.gponline.com/dauk-urges-rethink-gmc-fees-doctors-taking-parental-lea


Which areas are moving fastest towards a safe GP-patient ratio?

17:09 - 16/02/2026
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Across England as a whole, the average GP was responsible for 40 fewer patients at the end of 2025 than 12 months earlier. But some areas have moved the dial far faster - GPonline looks at how the picture varies across England.

https://www.gponline.com/areas-moving-fastest-towards-safe-gp-patient-ratio/arti


Which parts of England are furthest behind as child vaccine PR campaign begins?

11:39 - 16/02/2026
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The government has launched a campaign to encourage increased uptake of child vaccinations - but which parts of England have furthest to go to achieve effective coverage?

https://www.gponline.com/parts-england-furthest-behind-child-vaccine-pr-campaign


NHS staff to receive 3.3% pay uplift for 2026/27

09:52 - 13/02/2026
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NHS staff in England paid under Agenda for Change will receive a 3.3% pay increase in 2026/27, the government has announced.

https://www.gponline.com/nhs-staff-receive-33-pay-uplift-2026-27/article/1948356


English GP-led company hands back final three Welsh GP contracts

16:29 - 12/02/2026
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An England-based GP-led company, which has faced intense scrutiny over how its surgeries are managed, has handed back its remaining three GP practice contracts in Wales.

https://www.gponline.com/english-gp-led-company-hands-back-final-three-welsh-gp-


CQC to pilot new GP-specific inspection framework this spring

09:05 - 13/02/2026
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The CQC is set to scrap its universal assessment approach and is expecting to begin pilots of a new sector-specific framework for general practice in spring this year, the new chief inspector for primary care and community services has said.

https://www.gponline.com/cqc-pilot-new-gp-specific-inspection-framework-spring/a


Podcast: How CQC regulation of general practice is changing

08:26 - 13/02/2026
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Talking General Practice speaks to CQC chief inspector of primary care and community services Professor Bola Owolabi.

https://www.gponline.com/podcast-cqc-regulation-general-practice-changing/articl


MPs raise concerns over GP funding formula review

11:08 - 12/02/2026
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The government has insisted a review of the Carr-Hill formula used to share out core general practice funding will not 'rob Peter to pay Paul' after MPs raised concerns in a debate on funding for rural general practice.

https://www.gponline.com/mps-raise-concerns-gp-funding-formula-review/article/19


Jamanetwork.com


Audio Highlights January 23, 2026

00:00 - 17/02/2026
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Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

https://jamanetwork.com/journals/jama/fullarticle/2844472


Decline in US Overdose Deaths May Be Tied to Fentanyl Supply Disruption

00:00 - 17/02/2026
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Opioid overdose deaths in the US dropped dramatically in 2023. And a new analysis suggests that a fentanyl supply disruption may account for a substantial part of the decline.

https://jamanetwork.com/journals/jama/fullarticle/2844459


Limited Evidence Supporting Melatonin Use in Most Children

00:00 - 17/02/2026
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Amid a global rise in melatonin prescriptions, a systematic review found limited evidence on its efficacy in young children with typical neurological development.

https://jamanetwork.com/journals/jama/fullarticle/2844458


Alcohol-Related Hospitalizations Stabilize, but Deaths and Costs Rise

00:00 - 17/02/2026
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Findings suggest that alcohol-related hospitalizations remained stable in the US from 2016 to 2022, but length of stay, mortality rates, and costs all increased.

https://jamanetwork.com/journals/jama/fullarticle/2844457


Long-Term CVD Risk Associated With Very High Lipoprotein(a) Levels in Women

00:00 - 17/02/2026
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Women with very high lipoprotein(a) levels may have an increased 30-year risk of cardiovascular disease (CVD), new research found.

https://jamanetwork.com/journals/jama/fullarticle/2844456


Higher Food Preservative Intake Linked With Type 2 Diabetes

00:00 - 17/02/2026
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People who consume more food preservatives may have a greater risk of type 2 diabetes, according to a study published in Nature Communications.

https://jamanetwork.com/journals/jama/fullarticle/2844455


Combination Pills May Improve Hypertension

00:00 - 17/02/2026
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A scientific statement from the American Heart Association pointed toward combination pills to improve high blood pressure.

https://jamanetwork.com/journals/jama/fullarticle/2844454


New Insight on Stress and Cardiovascular Disease

00:00 - 17/02/2026
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This Medical News article examines research suggesting that stress may mediate the observed association of depression and anxiety with major cardiovascular events.

https://jamanetwork.com/journals/jama/fullarticle/2844453


Heredity and Obesity

00:00 - 17/02/2026
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The statement, frequently encountered, that obesity is merely the expression of an excess of intake of food over the bodily expenditures, is far from satisfactory to a critical student of the subject. There are at least a few obese persons who are fairly active in their habits and frugal in their diets; these, Du Bois remarks, furnish us with the true problem of obesity. A question that obviously presents itself in this connection concerns the basal metabolism of the aberrant types. Do they differ from the [average] by carrying out their fundamental exchange of energy more economically? This has been a question not easily answered, because of the difficulties of making tenable comparisons between the different persons concerned.

https://jamanetwork.com/journals/jama/fullarticle/2844190


Jamanetwork.com Open

Errors in Key Points, Abstract, Results, and Discussion

00:00 - 17/02/2026
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In the Original Investigation titled “Subsequent Meningiomas Among Survivors of Childhood Cancer,” published December 11, 2025, there were errors in the Key Points, Abstract, Results, and Discussion, in which it was incorrectly reported that 6-mercaptopurine (6-MP) was the antimetabolite exposure. However, in all analyses, the antimetabolite exposure was actually modeled as a composite class variable that included methotrexate, 6-MP, 6-thioguanine, and cytarabin. The language throughout the article has been updated to antimetabolite chemotherapy. The authors have explained the error in a Comment.2 This article has been corrected.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845154





Sessile Serrated Lesion Detection Rate and Colorectal Cancer Risk and Mortality

00:00 - 17/02/2026
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This cohort study evaluates whether the sessile serrated lesion detection rate is associated with risk of postcolonoscopy colorectal cancer and related mortality.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845150


Leisure-Time Physical Activity and Cancer Mortality

00:00 - 17/02/2026
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This pooled analysis of 6 cohort studies evaluates whether participating in moderate to vigorous physical activity after a cancer diagnosis is associated with longer survival among individuals with a history of bladder, endometrial, kidney, lung, oral, ovarian, or rectal cancer.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845149


Initial Imaging for Adults With Maxillofacial Trauma in a National Claims Database

00:00 - 17/02/2026
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This cohort study examines prevalence of and factors associated with use of low-value plain radiography vs guideline-recommended computed tomography as the initial imaging for adults with maxillofacial trauma.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845148


Adjuvant Pembrolizumab for Stage IIB or IIC Melanoma

00:00 - 17/02/2026
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This secondary analysis of a randomized clinical trial assesses new skin cancers, recurrence-free survival with new melanomas considered events, and immune-mediated severe skin reactions among patients receiving pembrolizumab or placebo for stage II melanoma.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845147


Chronic Kidney Disease Severity and Risk of Cognitive Impairment

00:00 - 17/02/2026
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This cohort study of participants in the Chronic Renal Insufficiency Cohort investigates whether chronic kidney disease severity is associated with incident cognitive impairment.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845146


Racial, Ethnic, and Sex Differences in Social Risk-Needs Concordance

00:00 - 17/02/2026
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This cross-sectional study examines the agreement between self-reported social risks and needs for support and variance in risk-need concordance across racial, ethnic, and sex subgroups of US veterans.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845145