[Comment] Continued hope for late neuroprotection with minocycline

00:00 - 30 Jan 2026

Neuroprotection in ischaemic stroke commonly means a treatment that results in the preservation of brain tissue in the setting of either focal or global ischaemia. The nominal focus on neuronal tissue—the neuro in neuroprotection—might be misplaced, as the ultimate goal is preservation of the entirety of the relevant tissue, including neurons, glia, vascular elements, and structural tissue. Cytoprotection of the neurovascular unit1 could be a better term.2 Neuronal intolerance to ischaemia is highly time dependent, and mechanisms to protect neurons could also protect and salvage other cellular elements that remain viable after longer durations of ischaemia.