Nature, Published online: 17 February 2026; doi:10.1038/s41586-026-10249-5

Publisher Correction: Psychedelics elicit their effects by 5-HT2A receptor-mediated G_i signalling

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00497-w

Smartphones are a double-edged tool in classrooms

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00297-2

Practical physics classes were competing with the allure of sports in the 1800s, and top tips for the best-smelling garden, in this week’s peek at the Nature archives.

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00495-y

Statistical approximation is not general intelligence

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00498-9

The funding system needs fixing — but it’s not a ‘waste of time and money’

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00496-x

What’s behind ‘teensplaining’? Scientists should study this adolescent behaviour

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00469-0

Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00349-7

Study could help reveal why some mental health disorders vary between men and women — but it's not clear whether the differences are due to sex or gender.

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00474-3

To ensure that AI advances benefit everyone, scientific institutions must prioritize collaborative, mission-driven structures instead of chasing top talent with astronomical compensation.

Nature, Published online: 17 February 2026; doi:10.1038/d41586-026-00439-6

A European project calls for help to verify whether carbon quantum dots are really able to sense chemicals in cells.

For decades, depictions of Triceratops and its kin have been driven by bone alone. Now, paleontologists in Japan have mapped the soft-tissue anatomy of these horned dinosaurs, revealing unexpected structures that may explain how they regulated temperature and breathed.

The post Triceratops’ Oversized Nasal Cavities Played Roles Far Beyond Smell, Paleontologists Find appeared first on Sci.News: Breaking Science News.

Scientists have isolated a new strain of the Psychrobacter cryohalolentis species from 5,000-year-old ice from Scarisoara Ice Cave in Romania.

The post Multidrug-Resistant Bacterial Strain Found Preserved in 5,000-Year-Old Cave Ice appeared first on Sci.News: Breaking Science News.

In a new study, scientists at the Max Planck Institute for Intelligent Systems aimed to characterize the geometry, porosity, and stiffness of Asian elephant (Elephas maximus) whiskers.

The post Remarkable Sense of Touch in Elephant’s Trunk Isn’t Just about Muscles or Nerves: Study appeared first on Sci.News: Breaking Science News.

Paleontologists have unearthed fossilized bones of one of the smallest sauropodomorph dinosaurs from the Late Triassic of southern Brazil, offering fresh insights into early dinosaur development and physiology.

The post Small Triassic Dinosaur from Brazil Sheds New Light on Sauropodomorph Growth Strategies appeared first on Sci.News: Breaking Science News.

A new study by scientists from the University of Bergen, NASA’s Goddard Space Flight Center and the University of Oxford suggests that strange plume-like structures hidden deep within the Greenland Ice Sheet are caused by thermal convection.

The post Researchers Solve Mystery of Swirling, Plume-Like Structures Deep Inside Greenland’s Ice Sheet appeared first on Sci.News: Breaking Science News.

Astronomers using the NASA/ESA/CSA James Webb Space Telescope have for the first time identified hydrogen sulfide gas in the atmospheres of three gas-giant exoplanets orbiting HR 8799, a 30-million-year-old star located in the constellation of Pegasus.

The post Webb Detects Hydrogen Sulfide Gas on Three Super-Jupiters appeared first on Sci.News: Breaking Science News.

New research by geoscientists from the University of Florida and the Institut de Physique du Globe de Paris traces the origins of the Antarctic gravity hole (or the Antarctic Geoid Low) to slow, subterranean rock flows over tens of millions of years.

The post Geoscientists Pinpoint Ancient Forces behind Antarctica’s Gravity Hole appeared first on Sci.News: Breaking Science News.

The Chandra team has released a striking new composite image of the Cocoon Nebula, a reflection and emission nebula in the constellation of Cygnus.

The post Chandra Spots Cluster of Newborn Stars in Cocoon Nebula appeared first on Sci.News: Breaking Science News.

Between 73,000 and 20,000 years ago (Late Pleistocene), the Japanese Archipelago was inhabited by cave lions (Panthera spelaea), according to a new genetic and proteomic analysis of fossilized felid remains previously attributed to tigers (Panthera tigris).

The post Japanese Archipelago Was Once a Refuge for Cave Lions appeared first on Sci.News: Breaking Science News.

Using archival data from NASA’s NEOWISE mission along with data from other space and ground-based observatories, astronomers identified the clearest observational record yet of a massive star fading and vanishing into a black hole -- an event once theorized but rarely seen.

The post Supergiant Star Collapsed into Stellar-Mass Black Hole in Andromeda Galaxy appeared first on Sci.News: Breaking Science News.

New measurements could help predict pollinators’ ability to withstand climate change

Two intellectual property lawyers on why questions of AI inventorship and profit remain wide open

Researchers identify a complex that hands mimivirus control of protein synthesis in infected amoebae

Inoculating soil with pink microbes could help reduce the use of toxic insecticides.

Health department declines to renew Lindsey Criswell, head of arthritis institute, to another 5-year term

Last year’s mass firings of “probationary” federal workers sent researchers’ lives into turmoil

Agency’s attempt to overturn 2009 “endangerment finding” appears headed for Supreme Court

Failed supernova candidate points to a stealthy pathway of stellar collapse

Some RNA molecules can create their own mirror images, suggesting similar molecules could have sparked life

Students seeking graduate research scholarships speculate that biology is being disfavored

A technology that uses a coiled wire to electrify aerosols has boosted snowfall amid a drought in the western US, according to the company developing it, but the results haven't convinced other scientists

An ultrastable laser could enable extremely precise timing and navigation on the moon, and the cold, dark craters near the lunar poles would be the ideal location for it

The evolution of human hands is one of the most important – and overlooked – stories of our origin. Now, new fossil evidence is revealing their pivotal role

A giant virus encodes part of the protein-making toolkit of cells that gives it greater control over its amoeba host, raising questions about how it evolved and how such beings relate to living organisms

Hearing a sound while working on a complex puzzle, and then hearing it again during sleep, helped lucid dreamers better tackle the problem the next day

A mathematical equivalent of a microscope with variable resolution has shed light on why some atoms are exceptionally stable, a riddle that has persisted in nuclear physics for decades

The psychedelic DMT has been linked to improved mental health outcomes before, but now, scientists have shown it reduces depression symptoms more than a placebo when given alongside therapeutic support

The big bang wasn’t the start of everything, but it has been impossible to see what came before. Now a new kind of cosmology is lifting the veil on the beginning of time

Biologists have debated the reason why Homo sapiens evolved a prominent lower jaw, but this unique feature may actually be a by-product of other traits shaped by natural selection

We are used to heat flowing from hot objects to cool ones, and never the other way round, but now researchers have found it is possible to pull off this trick in the strange realm of quantum mechanics

Refugees from Ukraine who suffer from potential war trauma are less likely to work than their compatriots who do not. This is the result of a study published as an RFBerlin discussion paper.

Northern Japan, especially the island of Hokkaido, is home to some of the snowiest cities in the world. Sapporo, the island's largest city and host of an annual snow festival, typically sees more than 140 days of snowfall, with nearly six meters (20 feet) accumulating on average each year. The ski resorts surrounding the city delight in the relatively dry, powdery "sea-effect" snow that often falls when frigid air from Siberia flows across the relatively warm waters of the Sea of Japan.

Imagine someone has chronic pain. One doctor focuses on the body part that hurts and keeps trying to fix that single symptom. Another uses a more comprehensive brain-body approach and tries to understand what's keeping the nervous system stuck in alarm mode—perhaps stress, fear of symptoms or learned triggers. Because they're looking at the problem differently, they'll resort to completely different treatments.

The value of wetlands on the landscape cannot be overstated—they store and filter water, provide wildlife habitat, cool the atmosphere and sequester carbon. Yet, in the farmland area of Canada's Prairies, wetlands are being drained to increase crop production and expand urban development.

It's long been assumed the Jomon people, who had inhabited the Japanese archipelago since around 16,000 years ago, had multiple lineages resulting from different migration routes. But new genetic evidence, including mitochondrial DNA from 13 newly sequenced Jomon skeletons, suggests that an initial migration of a single lineage later split, giving rise to regional diversity. The findings are published in the journal Anthropological Science.

What does it mean to love your job? The language of love has become increasingly common in contemporary discussions of work. People say they want to love their jobs, organizations promise roles candidates will love, and recruitment ads frame employment as an emotional commitment rather than an economic transaction.

Frank Cuozzo and Michelle Sauther first traveled to South Africa in 2012 to search for some of the most unusual primates on Earth—bushbabies. These animals are nocturnal and small, often around the size of a housecat. Bushbabies have big ears, round eyes and get their names from the eerie, wailing noises they make at night.

Thousands of people were killed by Iranian security forces in days of protests in January 2026. Meanwhile, in the same month, the killing of two protesters in Minneapolis shone a light on the use of fatal force by American law enforcement—a phenomenon that in 2025 saw the deaths of more than 1,300 people in the U.S., according to data tracking such incidents.

The role of soil and forests in greenhouse gas sequestration has been studied for a long time. However, forests are also home to invisible organisms that may affect the climate. "Soil, water and peatlands have been studied in the Biogeochemistry Research Group at the University of Eastern Finland since the mid-1980s, led by Professor Emeritus Pertti Martikainen. When Martikainen retired in 2016, Professor of Microbial Biogeochemistry Jukka Pumpanen took over as the group's leader," says Academy Research Fellow Henri Siljanen from the Department of Environmental and Biological Sciences.

Most Hawaiʻi residents believe sea level rise is already affecting the state, expect major impacts within their lifetimes, and support significant changes to how and where development occurs. At the same time, many remain uncertain about how large-scale adaptation should be financed.

Quasicrystals are orderly structures that never repeat. Scientists just showed they can exist in space and time.

The complex biology of ghrelin, the hunger hormone, has researchers wondering how its absence helps snakes last a long time with no food, if at all.

In The Story of Stories, technologist Kevin Ashton explores how storytelling has evolved and why stories matter.

Subtle shifts in how users described symptoms to AI chatbots led to dramatically different, sometimes dangerous medical advice.

New plankton arrived just a few millennia — maybe even decades — after the Chicxulub asteroid, forcing a rethink of evolution's catastrophe response speed.

In Cape Verde, conservation has boosted the sea turtle population 100-fold — but the male-female balance is way off.

Solve the crossword from our March 2026 issue, in which we work on our code-switching.

A rocky exoplanet in the LHS 1903 system defies planet formation models, hinting that gravitational upheaval reshaped the red dwarf’s four worlds.

A lung cancer trial bolsters a long-held idea that treatment timing matters, showing a simple shift could help immunotherapy work better and extend lives.

A student created a low-cost baby carrier that filters sunlight to safely treat jaundice where electricity and equipment are scarce.

More than 30 years after the Scandinavian Simvastatin Survival Study showed that statins save lives, their full public health potential remains unrealised. Statins are underused worldwide, and as a result, millions of people remain at risk of cardiovascular events that statins could help prevent. The reasons for this implementation gap are complex, but persistent concerns about safety continue to affect both prescribing practices and adherence. Fear of side-effects—such as muscle pain, fatigue, sleep disturbances, and perceived cognitive effects—is a major driver of statin therapy discontinuation, even though randomised nocebo trials have shown that most reported symptoms are attributable to expectation rather than to the drug itself.

Neuroprotection in ischaemic stroke commonly means a treatment that results in the preservation of brain tissue in the setting of either focal or global ischaemia. The nominal focus on neuronal tissue—the neuro in neuroprotection—might be misplaced, as the ultimate goal is preservation of the entirety of the relevant tissue, including neurons, glia, vascular elements, and structural tissue. Cytoprotection of the neurovascular unit1 could be a better term.2 Neuronal intolerance to ischaemia is highly time dependent, and mechanisms to protect neurons could also protect and salvage other cellular elements that remain viable after longer durations of ischaemia.

Following the frequent suspicions regarding the safety of cholesterol-lowering drugs in the pre-statin era,1 statins have been a recurrent object of various concerns and alarming news. For example, during the 1990s, statins were even suspected to promote serious non-vascular outcomes, such as cancer.2 But after the clear-cut results of the Scandinavian Simvastatin Survival Study (4S), which showed the reduction of all-cause mortality in patients with coronary disease,3 and several large-scale clinical trials with corroborating evidence,4 concerns would have been expected to be silenced, but these concerns have persisted in cholesterol sceptics.

Primary care faces a growing workload and limited resources, making it the ideal recipient of the efficiencies promised by artificial intelligence (AI). The potential of AI to improve diagnostic accuracy through decision support systems or image analysis is clear.1–3 However, implementing these tools into primary care workflows remains challenging. Integration into the electronic health record (EHR), management of automation bias, and disruption of the physician–patient relationship are persistent challenges that must be incorporated into the study design itself using pragmatic trials.

Struck by substantial funding cuts throughout 2025, the global health community stands at a crossroads.1 Notwithstanding the grave consequences of decreased international financing, this crisis offers an unprecedented chance to address the well known flaws in the current system. Although the notion that we should first stabilise and later transform the global health landscape has gained traction, it fails to recognise that the present sense of urgency is precisely what makes systemic change possible, and that those two processes should therefore happen in tandem.

As financial actors including private equity funds increasingly buy and sell hospitals, nursing homes, and physician practices, real estate investment trusts (REITs) have emerged as a form of financial ownership in which the REIT owns the real estate properies of health-care facilities and health-care providers pay rent to the REIT.1 Given the rise of REITs in health care and their expanding global influence, policy makers should take a proactive stance towards regulating health-care REITs to disincentivise short-term profiteering and encourage long-term health-care investments that promote patient access and health-care quality.

Following the publication of this Case Report by Gideon Koren and colleagues1 in 2006, concerns were raised about its interpretation by D Nicholas Bateman and colleagues and we published a Correspondence exchange and an accompanying Comment in 2008.2–4 In 2020, further doubts about the plausibility were raised by David N Juurlink, who asked us to retract the paper and subsequently outlined in a Mini-Review5 together with his colleague Jonathan Zipursky his reasoning for the implausibility of this infant's death being caused through codeine in breastmilk.

So here we are. An email last week: “tensions are very high...one has little control over the chaos of the moment. I'm so angry, and so sad. It's exhausting”. These feelings, I suspect, are pervasive. A fractured world order, with the dismantling of systems that have shaped and stabilised societies, has provoked a surge of uncertainty. People are apprehensive, uneasy, fearful, troubled, disturbed, tense, even distraught. One can understand why. A cruel war of attrition in Ukraine. A terrifying humanitarian catastrophe in Sudan.

Both the UK and US Governments have pledged to end research using animals, but is such a goal realistic? And how might it change medical research? Talha Burki reports.

A lack of factor IX and factor VIII has left patients facing disability or death. Samaan Lateef reports.

On Jan 7, 2026, the US Departments of Health and Human Services (HHS) and Agriculture (USDA) published the 10th edition of the Dietary Guidelines for Americans (DGA).1 The new DGA are consequential, shaping personal nutritional advice and federal programmes until 2030. Yet the new DGA upended a rigorous, transparent process developed over decades and substituted a conflicted and compromised process that produced contradictory and often unscientific guidelines.

The 2025–2030 Dietary Guidelines for Americans, jointly issued by the US Departments of Health and Human Services and Agriculture, introduce a revised dietary pyramid that prioritises animal-based protein sources, full-fat dairy products, and saturated fats.1 We wish to comment on the extent to which this framework is supported by, and coherent with, the current body of global nutritional evidence.

The mass starvation in Gaza has called into question how famine is defined and measured. On Aug 22, 2025, the Famine Review Committee of the Integrated Food Security Phase Classification (IPC) determined that the food situation in Gaza Governorate had reached phase 5: famine.1 This famine status followed repeated warnings from humanitarian organisations and medical professionals that starvation deaths and acute malnutrition among children were rising sharply due to Israeli Government policies and Israel Defense Forces' actions in the Gaza Strip, including denying humanitarian aid.

In patients with relapsed or refractory MZL, lisocabtagene maraleucel showed high rates of durable responses. The safety profile was manageable, with no new safety signals. These results support lisocabtagene maraleucel as a new treatment option for patients with relapsed or refractory MZL.

Despite the availability of effective antihypertensive therapies, global blood pressure control rates remain unacceptably low. Contributing factors, such as low treatment adherence, therapeutic inertia, and rising multimorbidity, underscore the need for innovative approaches to improve hypertension care. New antihypertensive drug therapies that act on physiological pathways beyond those targeted by conventional drug classes are emerging. These therapies include small interfering RNA agents that inhibit angiotensinogen synthesis as a novel approach to inhibit the renin–angiotensin system, and new strategies to more selectively modulate aldosterone, such as aldosterone synthase inhibitors and non-steroidal mineralocorticoid receptor antagonists.

Obesity is associated with multiple non-communicable diseases (such as type 2 diabetes, various cardiovascular and musculoskeletal diseases, and some cancers) and detrimental psychosocial consequences originating in the societal attitudes to obesity, leading to stigmatisation and discrimination.1 The contribution of obesity to communicable diseases has been recognised in the past but thought to play a minor role.2,3 However, during the recent COVID-19 pandemic, presence of obesity and its comorbidities appeared to be an important risk factor for a severe course of the infection.

Adult obesity is a risk factor for infection-related hospitalisations and mortality across diverse pathogen types, populations, and baseline clinical profiles, with evidence suggesting that approximately one in ten infection-related deaths worldwide might be attributable to obesity.

Global health faces unprecedented strain and challenges to its legitimacy. The health-related Sustainable Development Goals and progress towards universal health coverage are off track, and multilateral cooperation is suffering due to geopolitical tensions. The future of global health is likely to be less aid-based and more reliant on domestic financing in low-income and middle-income countries (LMICs), more equitable markets for access to health technologies and digitally mediated treatment guidelines, and strengthened country capabilities.

The US military strikes on Venezuela on Jan 3, 2026 and seizure of the country's President Nicolás Maduro represent a profound shock to a health system already in collapse. With US President Donald Trump asserting that the US Government will run Venezuela for an unspecified period,1 the question is stark: will this claimed stabilisation help restore essential health services or will it deepen disruption and affect the most vulnerable populations?

Basilar artery occlusion is a devastating condition with dismal prognosis and constitutes the most severe presentation of acute ischaemic stroke due to large-vessel occlusion.1 Randomised evidence on the safety and efficacy of intravenous thrombolysis in this stroke subtype is scarce, especially outside the conventional 0–4·5 h window.1,2 Tenecteplase is a third-generation tissue plasminogen activator with higher fibrin specificity and longer half-life than alteplase.3 Accruing randomised and observational evidence supports the superiority of tenecteplase over alteplase in patients who have had an acute ischaemic stroke, particularly those with large-vessel occlusion, in improving 3-month functional outcome assessed by the modified Rankin scale (mRS) score.

An Apple iPad device stationed outside of a hospital room glows yellow, indicating that the patient inside is a fall risk. Before the clinician enters, she touches the screen to view other updates and confirm that she doesn’t need to first check in at the nurse’s station. Inside, a digital whiteboard displays information typically handwritten on a hospital room dry-erase board, such as dietary restrictions and the names of the current care staff. Because the interactive screen is connected to the electronic health record system, the data is updated in real time and can include physical...

A connecting theme during the 2025 LeadingAge Annual Meeting last fall was the importance of involving older adults in the adoption of new technologies that are meant to help with their care. They’re a large, growing market, yet their needs may not be met with newer designs. “The assumption is that older adults don’t like technology, or that they don’t use it, or that they’re afraid of it, or that they don’t understand it. What we’ve really found is that that’s not the case,” Michelle Curnow, senior vice president of sales and brand at Asbury Communities, said during a conference...

A content management program in healthcare needs to be fully secure, protecting data at rest and in transit, with varying security levels for content being held and managed by the platform. Ideally, data should be standardized so that multiple platforms are not required, and users should be trained on a single content management platform, regardless of which department they work in. The cloud-based Box Intelligent Content Management platform was created to meet the needs of even the most rigorously regulated and protected environments. I recently tested Box in a lab environment, and...

Last year, Mayo Clinic launched Nurse Virtual Assistant, a generative artificial intelligence tool designed by and for nurses to ease access to patient care, institutional and industry information. Instead of spending hours sifting through the electronic health record system or a clinical policy library, Nurse Virtual Assistant curates a summary in one place. As a large healthcare organization, Mayo Clinic built its solution in-house and will continue to refine it with direct feedback from nurses. Such a tool may feel out of reach for many healthcare providers, but the lesson here is that...

As hospitals and health systems layer artificial intelligence–driven analytics, clinical decision support and automation onto already complex IT environments, cloud costs are becoming harder to predict — and even harder to control. The challenge is no longer simply choosing between on-premises and public cloud but learning how to operate both intelligently at the same time. To keep costs under control, organizations must combine robust FinOps practices with a clear approach to cloud cost governance that aligns technology decisions with clinical, operational and financial priorities. DISCOVER...

In the wake of a new wave of artificial intelligence tools, healthcare organizations are embracing innovation on a larger scale. The promise of increased efficiency is attractive as the industry faces rising costs of care, demand for seamless patient experiences and growing cybersecurity complexity. While health systems are adopting AI tools on a larger scale, the speed of innovation has forced many to re-evaluate their technology foundations — infrastructure, data governance, cybersecurity — to ensure they can take advantage of AI to the fullest. This year, HealthTech expects healthcare...

It could take a supercomputer 149 million years to decrypt data that has been encrypted with the RSA-2048 public-key encryption system. A quantum computer might be able to crack that data in eight hours. While quantum computers with this capability don’t yet exist, experts predict they may become available roughly over the next decade. But the power of quantum computing represents an issue that healthcare organizations should start addressing now. “Cryptographers have known for a few decades that if we are able to build a big enough quantum computer, it will threaten all of the public-key...

Despite healthcare’s increasingly digitized workflows, paper will find its way in, especially when there are still patients who prefer having hard copies in hand. For those cases, and for caregivers on the go, the Brother PocketJet 823 mobile printer is a fitting solution. Paramedics and mobile health clinics especially will find uses for this handy portable printer. Providers who need to print receipts, test results or other important documents can rely on this portable thermal printer when paper workflows are needed in a mobile setting, whether working as a visiting nurse or specialist...

Artificial intelligence is transforming healthcare at a pace few could have imagined even six years ago. But nursing informatics professionals who understand patient care and data science are central to preparing an AI-ready clinical workforce. In my experience across hospitals, academia and consulting, I’ve learned that technology alone does not improve patient care — people do. As digital transformation accelerates, nurses remain essential to ensuring that AI increases patient safety rather than introducing new risks. Nursing informatics provides the bridge between innovation and practice,...

Virtualization allows institutions such as health systems to access applications virtually from a single machine and distribute them to other computing environments throughout the organization. In fact, virtualization is the technology that enables cloud computing environments. In 2023, Broadcom acquired VMware, and health systems have been evaluating what that means for their virtualization strategy. However, Broadcom is still offering VMware software, such as VMware Cloud Foundation (VCF), which delivers both the scale of public cloud and the security of private cloud. Broadcom now offers a...

New guidance hailed by NICE as the biggest shakeup of diabetes care in a decade could prevent around 17,000 deaths over three years and save the NHS hundreds of millions of pounds.

Next year's GP contract - expected imminently - will see a stronger focus on diabetes and child vaccination, NHS officials have said.

The Doctors’ Association UK (DAUK) wants the GMC to introduce a specific fee reduction for doctors, including GPs, who take parental leave.

Across England as a whole, the average GP was responsible for 40 fewer patients at the end of 2025 than 12 months earlier. But some areas have moved the dial far faster - GPonline looks at how the picture varies across England.

The government has launched a campaign to encourage increased uptake of child vaccinations - but which parts of England have furthest to go to achieve effective coverage?

NHS staff in England paid under Agenda for Change will receive a 3.3% pay increase in 2026/27, the government has announced.

An England-based GP-led company, which has faced intense scrutiny over how its surgeries are managed, has handed back its remaining three GP practice contracts in Wales.

The CQC is set to scrap its universal assessment approach and is expecting to begin pilots of a new sector-specific framework for general practice in spring this year, the new chief inspector for primary care and community services has said.

Talking General Practice speaks to CQC chief inspector of primary care and community services Professor Bola Owolabi.

The government has insisted a review of the Carr-Hill formula used to share out core general practice funding will not 'rob Peter to pay Paul' after MPs raised concerns in a debate on funding for rural general practice.

Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

Opioid overdose deaths in the US dropped dramatically in 2023. And a new analysis suggests that a fentanyl supply disruption may account for a substantial part of the decline.

Amid a global rise in melatonin prescriptions, a systematic review found limited evidence on its efficacy in young children with typical neurological development.

Findings suggest that alcohol-related hospitalizations remained stable in the US from 2016 to 2022, but length of stay, mortality rates, and costs all increased.

Women with very high lipoprotein(a) levels may have an increased 30-year risk of cardiovascular disease (CVD), new research found.

People who consume more food preservatives may have a greater risk of type 2 diabetes, according to a study published in Nature Communications.

A scientific statement from the American Heart Association pointed toward combination pills to improve high blood pressure.

This Medical News article examines research suggesting that stress may mediate the observed association of depression and anxiety with major cardiovascular events.

The statement, frequently encountered, that obesity is merely the expression of an excess of intake of food over the bodily expenditures, is far from satisfactory to a critical student of the subject. There are at least a few obese persons who are fairly active in their habits and frugal in their diets; these, Du Bois remarks, furnish us with the true problem of obesity. A question that obviously presents itself in this connection concerns the basal metabolism of the aberrant types. Do they differ from the [average] by carrying out their fundamental exchange of energy more economically? This has been a question not easily answered, because of the difficulties of making tenable comparisons between the different persons concerned.

In the Original Investigation titled “Subsequent Meningiomas Among Survivors of Childhood Cancer,” published December 11, 2025, there were errors in the Key Points, Abstract, Results, and Discussion, in which it was incorrectly reported that 6-mercaptopurine (6-MP) was the antimetabolite exposure. However, in all analyses, the antimetabolite exposure was actually modeled as a composite class variable that included methotrexate, 6-MP, 6-thioguanine, and cytarabin. The language throughout the article has been updated to antimetabolite chemotherapy. The authors have explained the error in a Comment.2 This article has been corrected.

Gastroenterology and Hepatology

Nutrition, Obesity, Exercise

Health Policy

This cohort study evaluates whether the sessile serrated lesion detection rate is associated with risk of postcolonoscopy colorectal cancer and related mortality.

This pooled analysis of 6 cohort studies evaluates whether participating in moderate to vigorous physical activity after a cancer diagnosis is associated with longer survival among individuals with a history of bladder, endometrial, kidney, lung, oral, ovarian, or rectal cancer.

This cohort study examines prevalence of and factors associated with use of low-value plain radiography vs guideline-recommended computed tomography as the initial imaging for adults with maxillofacial trauma.

This secondary analysis of a randomized clinical trial assesses new skin cancers, recurrence-free survival with new melanomas considered events, and immune-mediated severe skin reactions among patients receiving pembrolizumab or placebo for stage II melanoma.

This cohort study of participants in the Chronic Renal Insufficiency Cohort investigates whether chronic kidney disease severity is associated with incident cognitive impairment.

This cross-sectional study examines the agreement between self-reported social risks and needs for support and variance in risk-need concordance across racial, ethnic, and sex subgroups of US veterans.