[Comment] Methoxyflurane: a promising non-intravenous, non-opioid analgesic

00:00 - 20 Nov 2025

Analgesia in the prehospital setting is a challenging but important priority for first responders. Retrospective military data indicate an association between early analgesia with morphine after injury and lower subsequent risk of long-term sequelae such as post-traumatic stress disorder.1 Yet, data show that the proportion of patients with pain receiving analgesia in the prehospital setting remains low.2,3 This small proportion might reflect difficulty in obtaining intravenous access and concerns regarding haemodynamic side-effects of many analgesic agents such as opioids.